133576-75-7

Basic information

• Product Name: (+)-(1S,2R)-1-Phenyl-2-(1-piperidinyl)propan-1-ol
• Synonyms: (+)-(1S,2R)-1-Phenyl-2-(1-piperidinyl)propan-1-ol
• CAS NO: 133576-75-7
• Molecular Weight: 219.327
• Mol File: 133576-75-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+)-(1S,2R)-1-Phenyl-2-(1-piperidinyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(1S,2R)-1-Phenyl-2-(1-piperidinyl)propan-1-ol(133576-75-7)
• EPA Substance Registry System: (+)-(1S,2R)-1-Phenyl-2-(1-piperidinyl)propan-1-ol(133576-75-7)

Safety Data

• Hazardous Substances Data: 133576-75-7(Hazardous Substances Data)

Upstream product

• 628-77-3 1,5-diiodopentane 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 111-24-0 1,5-dibromo-pentane 

Downstream Products

• 103-79-7 1-phenyl-acetone 

Relevant articles and documents

Enantioselective Conjugate Addition of Catalytically Generated Zinc Homoenolate

We report herein an enantioselective conjugate addition reaction of a zinc homoenolate, catalytically generated via ring opening of a cyclopropanol, to an α,β-unsaturated ketone. The reaction is promoted by a zinc aminoalkoxide catalyst generated from Et2Zn and a chiral β-amino alcohol to afford 1,6-diketones, which undergo, upon heating, intramolecular aldol condensation to furnish highly substituted cyclopentene derivatives with good to high enantioselectivities. The reaction has proved applicable to various 1-substituted cyclopropanols as well as chalcones and related enones. The chiral amino alcohol has proved to enable ligand-accelerated catalysis of the homoenolate generation and its conjugate addition. Positive nonlinear effects and lower reactivity of a racemic catalyst have been observed, which can be attributed to a stable and inactive heterochiral zinc aminoalkoxide dimer.

New chiral catalysts for the highly enantioselective addition of diethylzinc to aldehydes

Optically active amino thioacetate derivatives of (+)-norephedrine were found to act as effective catalysts for enantioselective addition of diethylzinc to aldehydes. This reaction provided optically active secondary alcohols with e.e. of up to >99%.