13359-22-3

Basic information

• Product Name: 2-(2,4-dichlorophenoxy)-N-hydroxyacetamide
• Synonyms: 2-(2,4-Dichlorophenoxy)-N-hydroxyacetamide; Acetamide, 2-(2,4-dichlorophenoxy)-N-hydroxy-
• CAS NO: 13359-22-3
• Molecular Formula: C₈H₇Cl₂NO₃
• Molecular Weight: 236.0521
• Mol File: 13359-22-3.mol
• Article Data: 1

Chemical Properties

• Density: 1.5g/cm³
• Refractive Index: 1.582
• CAS DataBase Reference: 2-(2,4-dichlorophenoxy)-N-hydroxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dichlorophenoxy)-N-hydroxyacetamide(13359-22-3)
• EPA Substance Registry System: 2-(2,4-dichlorophenoxy)-N-hydroxyacetamide(13359-22-3)

Safety Data

• Hazardous Substances Data: 13359-22-3(Hazardous Substances Data)

Usage

Chemical Class

Synthetic chemical compound

Function

Plant growth regulator and herbicide

Usage

Controlling weeds in agricultural and horticultural settings

Mechanism of Action

Inhibits the synthesis of a key growth hormone in plants, leading to stunted growth and eventual death

Concerns

Potential negative impacts on non-target species and the environment

Ongoing Research

To better understand its effects and develop safer alternatives for weed control

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 533-23-3 ethyl 2,4-dichlorophenoxyacetate 

Relevant articles and documents

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections

Two series of ω-phenoxy contained acylhydroxamic acids as novel urease inhibitors were designed and synthesized. Biological activity evaluations revealed that ω-phenoxypropinoylhydroxamic acids were more active than phenoxyacetohydroxamic acids. Out of these compounds, 3-(3,4-dichlorophenoxy)propionylhydroxamic acid c24 showed significant potency against urease in both cell free extract (IC50 = 0.061 ± 0.003 μM) and intact cell (IC50 = 0.89 ± 0.05 μM), being over 450- and 120-fold more potent than the clinically prescribed urease inhibitor AHA, repectively. Non-linear fitting of experimental data (V-[S]) suggested a mixed-type inhibition mechanism and a dual site binding mode of these compounds.