133591-35-2Relevant academic research and scientific papers
An efficient modification of ellipticine synthesis and preparation of 13-hydroxyellipticine
Dra?ínsky, Martin,Sejbal, Jan,Rygerová, Barbora,Stiborová, Marie
, p. 6893 - 6895 (2008/02/12)
A simple modification of a previously published ellipticine synthesis is reported, which decreases the reaction time and increases the yield and purity of the product. Benzylic oxidations of 1,4-dimethylcarbazole and ellipticine derivatives were studied and 13-hydroxyellipticine was prepared.
EFFICIENT SYNTHESIS OF 6-SUBSTITUTED 3-NITRO- AND -3-AMINO-1,4-DIMETHYLCARBAZOLES
Lancelot, Jean-Charles,Letois, Bertrand,Rault, Sylvain,Dung, Nguyen Huy,Saturnino, Carmela,Robba, Max
, p. 301 - 307 (2007/10/02)
The acylation of 1,4-dimethylcarbazole, 1, by an acid chloride or acetic anhydride according to the Friedel-Crafts reaction led to diacylcarbazoles 4, 6, 8, 10, 11 or to monoacylcarbazoles 5, 7, 9, 12, 13 and 14.The 3-acetyl-6-methoxy-6-nitrocarbazoles co
Etude de la cytotoxicite in vitro de derives du carbazole III. 3-Amino et 3-nitro-1,4-dimethyl-9H-carbazoles diversement substitutes en position 6
Letois, B,Lancelot, J C,Rault, S,Robba, M,Tabka, T,et al.
, p. 775 - 784 (2007/10/02)
The synthesis of a series of nitro and amino-1,4-dimethyl-9H-carbazoles is described.The cytotoxic activities, as assayed in vitro using clonogenic cell culture of murine leukemia L1210, vary greatly with the nature and position of substituents.The most cytotoxic derivatives, 3-amino-6-hydroxy 1,4-dimethyl-9H-carbazole, displays an activity similar to that of N2-methyl-9-hydroxy ellipticinium acetate (NMHE).These results, together with those previously published by us, allow a detailed analysis of structure-activity relationships in the 9H-carbazole and1,4-dimethyl-9H-carbazole series.For the 3-amino-1,4-dimethyl 9H-carbazole derivatives, a mechanism of action similar to that of ellipticine derivatives is proposed.
