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133593-36-9

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133593-36-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 133593-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,5,9 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133593-36:
(8*1)+(7*3)+(6*3)+(5*5)+(4*9)+(3*3)+(2*3)+(1*6)=129
129 % 10 = 9
So 133593-36-9 is a valid CAS Registry Number.

133593-36-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(pyrazin-2-yl)benzo[d]thiazole

1.2 Other means of identification

Product number -
Other names 2-Pyrazin-2-yl-benzothiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133593-36-9 SDS

133593-36-9Downstream Products

133593-36-9Relevant articles and documents

Application of cyclometalated rhodium(III) complexes as therapeutic agents in biomedical and luminescent cellular imaging

Amiri, Ahmad,Amirnasr, Mehdi,Bikhof Torbati, Maryam,Farrokhpour, Hossein,Lutz, Martin,Meghdadi, Soraia,Sohrabi, Marzieh

, (2021/10/14)

The synthesis and characterization of three [Rh(ppy)2(N^N)][PF6] complexes, [Rh(ppy)2(pybtz)][PF6].CH3OH (Rh1), [Rh(ppy)2(pzbtz)][PF6] (Rh2) and [Rh(ppy)2(qbtz)][PF6] (Rh3) [Hppy: 2-phenylpyridine; N^N: (pyridin-2-yl)benzo[d]thiazole (pybtz), (pyrazin-2-yl)benzo[d]thiazole (pzbtz), and (quinolin-2-yl)benzo[d]thiazole (qbtz)], and single crystal structures of Rh1 and Rh3 are reported. Rh1 and Rh3 show high fluorescent intensities upon excitation at 400 and 410 nm, respectively. Evaluation of lipophilicity by theoretical calculations indicates Rh3 > Rh1 > Rh2, introducing Rh3 as the best candidate for biological studies. The Rh3 exhibits anticancer activity, with high cellular uptake efficiency and good cytotoxicity against MCF-7 cell line as compared to the non-malignant MRC-5 cells. Flow cytometry have confirmed the apoptosis cell death and cell cycle arrest in the sub-G1 phase. The result of real time PCR shows that Rh3 induces apoptosis by up-regulating of p53, miR-15a, miR-16–1 and miR-29b and down regulating of bcl-2 and miR-21 at the level of RNA transcription. Importantly, cell imaging experiments have demonstrated that Rh3 can be considered as a new promising metallodrug candidate for cancer treatment.

Pd-Catalyzed Decarbonylative C?H Coupling of Azoles and Aromatic Esters

Matsushita, Kaoru,Takise, Ryosuke,Hisada, Tomoya,Suzuki, Shin,Isshiki, Ryota,Itami, Kenichiro,Muto, Kei,Yamaguchi, Junichiro

supporting information, p. 2393 - 2396 (2018/05/30)

A decarbonylative C?H coupling of azoles and aromatic esters by palladium catalysis is described. Our previously reported Ni-catalyzed C?H coupling of azoles and aromatic esters has a significant drawback regarding the substrate scope. Herein, we employ p

Mechanistic Insights into Pincer-Ligated Palladium-Catalyzed Arylation of Azoles with Aryl Iodides: Evidence of a PdII-PdIV-PdII Pathway

Khake, Shrikant M.,Jagtap, Rahul A.,Dangat, Yuvraj B.,Gonnade, Rajesh G.,Vanka, Kumar,Punji, Benudhar

supporting information, p. 875 - 886 (2016/04/19)

Pincer-based (R2POCNR′2)PdCl complexes along with CuI cocatalyst catalyze the arylation of azoles with aryl iodides to give the 2-arylated azole products. Herein, we report an extensive mechanistic investigation for the direct arylation of azoles involving a well-defined and highly efficient (iPr2POCNEt2)PdCl (2a) catalyst, which emphasizes a rare PdII-PdIV-PdII redox catalytic pathway. Kinetic studies and deuterium labeling experiments indicate that the C-H bond cleavage on azoles occurs via two distinct routes in a reversible manner. Controlled reactivity of the catalyst 2a underlines the iodo derivative (iPr2POCNEt2)PdI (3a) to be the resting state of the catalyst. The intermediate species (iPr2POCNEt2)Pd-benzothiazolyl (4a) has been isolated and structurally characterized. A determination of reaction rates of compound 4a with electronically different aryl iodides has revealed the kinetic significance of the oxidative addition of the C(sp2)-X electrophile, aryl iodide, to complex 4a. Furthermore, the reactivity behavior of 4a suggests that the arylation of benzothiazole proceeds via an oxidative addition/reductive elimination pathway involving a (iPr2POCNEt2)PdIV(benzothiazolyl)(Ar)I species, which is strongly supported by DFT calculations.

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