133605-26-2

Usage

Uses

Used in Organic Synthesis:
2-(BROMOMETHYL)-1-NITRO-3-(TRIFLUOROMETHYL)BENZENE is used as a building block in organic synthesis for the creation of more complex molecules. Its unique structure allows for various chemical reactions, making it a valuable component in the synthesis of advanced organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(BROMOMETHYL)-1-NITRO-3-(TRIFLUOROMETHYL)BENZENE serves as a key intermediate in the development of new pharmaceuticals. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final drug product.
Used in Pharmaceutical Industry:
2-(BROMOMETHYL)-1-NITRO-3-(TRIFLUOROMETHYL)BENZENE is utilized in the pharmaceutical industry for the synthesis of drugs with potential therapeutic applications. Its unique functional groups can be manipulated to create molecules with specific biological activities.
Used in Agrochemical Industry:
2-(BROMOMETHYL)-1-NITRO-3-(TRIFLUOROMETHYL)BENZENE also finds use in the agrochemical industry, where it can be employed in the synthesis of pesticides, herbicides, and other agricultural chemicals. Its reactive nature allows for the development of molecules with targeted effects on pests or weeds.
Safety Precautions:
Due to the highly reactive nature of 2-(BROMOMETHYL)-1-NITRO-3-(TRIFLUOROMETHYL)BENZENE, it is crucial to handle 2-(BROMOMETHYL)-1-NITRO-3-(TRIFLUOROMETHYL)BENZENE with care. Proper safety measures, including the use of personal protective equipment and adherence to laboratory safety protocols, should be taken to minimize potential hazards.

InChI:InChI=1/C8H5BrF3NO2/c9-4-5-6(8(10,11)12)2-1-3-7(5)13(14)15/h1-3H,4H2

Upstream product

• 6656-49-1 2-methyl-1-nitro-3-(trifluoromethyl)benzene 

Downstream Products

• 349150-78-3 (2-nitro-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester 
• 132898-39-6 2-(trifluoromethyl)-6-nitrobenzyl tosylate 
• 58579-47-8 (2-amino-6-trifluoromethyl-benzylamino)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Photoactivatable Sensors for Detecting Mobile Zinc

Fluorescent sensors for mobile zinc are valuable for studying complex biological systems. Because these sensors typically bind zinc rapidly and tightly, there has been little temporal control over the activity of the probe after its application to a sample. The ability to control the activity of a zinc sensor in vivo during imaging experiments would greatly improve the time resolution of the measurement. Here, we describe photoactivatable zinc sensors that can be triggered with short pulses of UV light. These probes are prepared by functionalizing a zinc sensor with protecting groups that render the probe insensitive to metal ions. Photoinduced removal of the protecting groups restores the binding site, allowing for zinc-responsive changes in fluorescence that can be observed in live cells and tissues.

BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIVARAL AGENTS

The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined in the specification, and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together

INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

2-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2λ6-benzo [1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors

Potent, selective, and structurally new inhibitors of the Fe(II) enzyme Escherichia coli peptide deformylase (PDF) were obtained by rational optimization of the weakly binding screening hit (5-chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydra

Resist materials

A class of resist compositions sensitive to deep ultraviolet radiation includes a resin sensitive to acid and a composition that generates acid upon exposure to such radiation. A group of nitrobenzyl materials is particularly suitable for use as the acid generator.

Process for the bromination of deactivated toluenes in the benzylic position

Deactivated toluene compounds such as 2-nitro-6-trifluoromethyltoluenes, are brominated by stepwise addition of bromine at elevated temperatures. Subsequent conversion of the resulting brominated toluene to the corresponding benzyl alcohol allows esterifi