133605-28-4 Usage
Uses
Used in Pharmaceutical Industry:
2-(Bromomethyl)-1-nitro-4-(trifluoromethyl)benzene is used as an intermediate for the synthesis of various pharmaceuticals. Its unique structure, featuring bromomethyl and trifluoromethyl groups, allows for the creation of a wide range of complex organic molecules that can be utilized in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Bromomethyl)-1-nitro-4-(trifluoromethyl)benzene is employed as an intermediate for the synthesis of agrochemicals. Its chemical properties make it a valuable component in the production of pesticides and other agricultural chemicals, contributing to the development of more effective and targeted products.
Used as a Reagent in Organic Synthesis:
2-(Bromomethyl)-1-nitro-4-(trifluoromethyl)benzene is also used as a reagent in organic synthesis reactions. Its presence on the benzene ring makes it a versatile building block for the preparation of a variety of complex organic molecules, which can be further utilized in various chemical processes and applications.
Safety Precautions:
It is important to handle 2-(Bromomethyl)-1-nitro-4-(trifluoromethyl)benzene with care, as it may be harmful if ingested or inhaled. Proper safety precautions should be taken when working with this chemical compound to ensure the safety of individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 133605-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,6,0 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 133605-28:
(8*1)+(7*3)+(6*3)+(5*6)+(4*0)+(3*5)+(2*2)+(1*8)=104
104 % 10 = 4
So 133605-28-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H5BrF3NO2/c9-4-5-3-6(8(10,11)12)1-2-7(5)13(14)15/h1-3H,4H2
133605-28-4Relevant academic research and scientific papers
A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction
McAllister, Laura A.,Bechle, Bruce M.,Dounay, Amy B.,Evrard, Edelweiss,Gan, Xinmin,Ghosh, Somraj,Kim, Ji-Young,Parikh, Vinod D.,Tuttle, Jamison B.,Verhoest, Patrick R.
, p. 3484 - 3497 (2011/06/24)
We describe a generalized approach to stereocontrolled synthesis of substituted cyclic hydroxamic acids (3-amino-1-hydroxy-3,4-dihydroquinolinones) by selective reduction of substituted 2-nitrophenylalanine substrates. Compounds in this series have antibacterial properties and have also recently been reported as KAT II inhibitors. The key nitrophenyl alanine intermediates are prepared enantioselectively in excellent yield by phase transfer catalyzed alkylation of the corresponding nitrobenzyl bromides. The scope and limitations of the reductive cyclization transformation have been explored with attention to the effects of substitution pattern and electronics on reaction efficiency and byproduct formation. In addition, a novel activated trifluoroethyl ester cyclization strategy has been developed as an alternate approach to the most sterically demanding systems in this series.
Resist materials
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, (2008/06/13)
A class of resist compositions sensitive to deep ultraviolet radiation includes a resin sensitive to acid and a composition that generates acid upon exposure to such radiation. A group of nitrobenzyl materials is particularly suitable for use as the acid generator.
