133605-28-4 Usage
General Description
2-(Bromomethyl)-1-nitro-4-(trifluoromethyl)benzene is a chemical compound with the molecular formula C8H6BrF3NO2. It is a nitrobenzene compound with a bromomethyl and trifluoromethyl group attached to the benzene ring. 2-(BROMOMETHYL)-1-NITRO-4-(TRIFLUOROMETHYL)BENZENE is primarily used as an intermediate for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis reactions. The presence of the bromomethyl and trifluoromethyl groups on the benzene ring make this compound a valuable building block for the preparation of complex organic molecules. However, it is important to handle this chemical with care as it may be harmful if ingested or inhaled, and proper safety precautions should be taken when working with it.
Check Digit Verification of cas no
The CAS Registry Mumber 133605-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,6,0 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 133605-28:
(8*1)+(7*3)+(6*3)+(5*6)+(4*0)+(3*5)+(2*2)+(1*8)=104
104 % 10 = 4
So 133605-28-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H5BrF3NO2/c9-4-5-3-6(8(10,11)12)1-2-7(5)13(14)15/h1-3H,4H2
133605-28-4Relevant articles and documents
A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction
McAllister, Laura A.,Bechle, Bruce M.,Dounay, Amy B.,Evrard, Edelweiss,Gan, Xinmin,Ghosh, Somraj,Kim, Ji-Young,Parikh, Vinod D.,Tuttle, Jamison B.,Verhoest, Patrick R.
experimental part, p. 3484 - 3497 (2011/06/24)
We describe a generalized approach to stereocontrolled synthesis of substituted cyclic hydroxamic acids (3-amino-1-hydroxy-3,4-dihydroquinolinones) by selective reduction of substituted 2-nitrophenylalanine substrates. Compounds in this series have antibacterial properties and have also recently been reported as KAT II inhibitors. The key nitrophenyl alanine intermediates are prepared enantioselectively in excellent yield by phase transfer catalyzed alkylation of the corresponding nitrobenzyl bromides. The scope and limitations of the reductive cyclization transformation have been explored with attention to the effects of substitution pattern and electronics on reaction efficiency and byproduct formation. In addition, a novel activated trifluoroethyl ester cyclization strategy has been developed as an alternate approach to the most sterically demanding systems in this series.