133613-71-5 Usage
Description
Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM. The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.
Uses
Different sources of media describe the Uses of 133613-71-5 differently. You can refer to the following data:
1. Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator. Recently it was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.
2. Galiellalactone is a STAT3 inhibitor; active in vivo. Galiellalactone is also a promising compound for the development of future prostate cancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 133613-71-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,6,1 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133613-71:
(8*1)+(7*3)+(6*3)+(5*6)+(4*1)+(3*3)+(2*7)+(1*1)=105
105 % 10 = 5
So 133613-71-5 is a valid CAS Registry Number.
133613-71-5Relevant articles and documents
Diastereoselective Total Synthesis of (-)-Galiellalactone
Kim, Taewoo,Han, Young Taek,An, Hongchan,Kim, Kyeojin,Lee, Jeeyeon,Suh, Young-Ger
, p. 12193 - 12200 (2015)
An enantioselective total synthesis of (-)-galiellalactone has been accomplished. The key features of the synthesis involve the highly stereoselective construction of the cis-trisubstituted cyclopentane intermediate by a Pd(0)-catalyzed cyclization, the stereospecific introduction of an angular hydroxyl group by Riley oxidation, and the efficient construction of the tricyclic system of (-)-galiellalactone via a combination of diastereoselective Hosomi-Sakurai crotylation and ring-closing metathesis (RCM)
Synthesis of (-)-galiellalactone
Johansson, Martin,Sterner, Olov
, p. 663 - 665 (2007/10/03)
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