13362-94-2Relevant articles and documents
Discovery of novel aldose reductase inhibitors characterized by an alkoxy-substituted phenylacetic acid core
Rakowitz, Dietmar,Gmeiner, Andreas,Matuszczak, Barbara
, p. 559 - 563 (2006)
In continuation of our effort aimed towards the development of novel aldose reductase inhibitors, several phenylacetic acids bearing an alkoxy substituent in position 3 or 4, respectively, were prepared and screened. The latter represent formal ring openi
COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES
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, (2019/03/12)
The present disclosure relates to compounds according to Formulae (I), (II) and (VIII), useful for treating diseases.
Synthesis method of 4-isobutoxy benzylamine
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, (2018/07/30)
The invention discloses a synthesis method of 4-isobutoxy benzylamine. 4-hydroxyphenylacetic acid serves as a raw material to generate 4-hydroxyphenylacetic acid methylester through an esterificationreaction; 4-hydroxyphenylacetic acid methylester is subjected to a substitution reaction to generate 4-methyl isobutoxyphenylacetic acid, and 4-isobutoxyphenylacetic acid is obtained after the obtained product is hydrolyzed; 4-isobutoxyphenylacetamide is generated through an acylation reaction; and N-(4-hydroxy benzyl)methyl carbamate is generated through a Hofmann degradation reaction, and a target product is obtained through hydrolysis. The raw materials used in the synthesis method are cheap and easy to get, the reaction condition is mild, post-treatment is simple, column chromatography isnot needed, the product can be obtained easily, and the yield is higher.