133635-43-5

Basic information

• Product Name: (S)-γ-(4-methylbenzoyloxymethyl)-γ-butyrolactone
• Synonyms: (S)-γ-(4-methylbenzoyloxymethyl)-γ-butyrolactone
• CAS NO: 133635-43-5
• Molecular Weight: 234.252
• Mol File: 133635-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-γ-(4-methylbenzoyloxymethyl)-γ-butyrolactone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-γ-(4-methylbenzoyloxymethyl)-γ-butyrolactone(133635-43-5)
• EPA Substance Registry System: (S)-γ-(4-methylbenzoyloxymethyl)-γ-butyrolactone(133635-43-5)

Safety Data

• Hazardous Substances Data: 133635-43-5(Hazardous Substances Data)

Upstream product

• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 133635-70-8 2',3'-dideoxy-5-O-(4-methylbenzoyl)-5-pentyloxymethylcytidine 
• 133635-70-8 1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine 
• 133635-59-3 5-benzyloxymethyl-2',3'-dideoxy-5-O-(4-methylbenzoyl)uridine 
• 133635-59-3 5-benzyloxymethyl-1-(2,3-dideoxxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)uracil 
• 133635-56-0 2',3'-dideoxy-5-O-(4-methylbenzoyl)-5-methoxymethyluridine 
• 133635-56-0 1-(2,3-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-methoxymethyluracil 
• 133635-55-9 2',3'-dideoxy-5'-O-(4-methylbenzoyl)-5-hydroxymethyluridine 
• 133698-19-8 1-(2,3-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-hydroxymethyluracil 
• 133635-62-8 2',3'-dideoxy-5-pentyloxymethyluridine 
• 133635-66-2 4-Methyl-benzoic acid (S)-5-(2-oxo-5-pentyloxymethyl-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 133635-65-1 4-Methyl-benzoic acid (S)-5-(5-sec-butoxymethyl-2-oxo-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 133635-58-2 4-Methyl-benzoic acid (S)-5-(2,4-dioxo-5-pentyloxymethyl-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 133635-53-7 4-Methyl-benzoic acid (S)-5-(2,6-dioxo-5-pentyloxymethyl-3,6-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 133635-54-8 4-Methyl-benzoic acid (S)-5-(5-benzyloxymethyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Synthesis of 2',3'-Dideoxynucleosides from 5-Alkoxymethyluracils

A modified synthesis of protected 2,3-dideoxyribose 5 starting from L-glutamic acid (1) is described.Reaction of 5 with silylated 5-hydroxymethyluracil 7a and 5-alkoxymethyluracils 7b-e in the presence of trimethylsilyl triflate afforded an anomeric mixture of 2',3'-dideoxyuridine derivatives 8a-e and 9a-e.Deprotection with methanolic ammonia and separation by chromatography gave the corresponding nucleosides 10a-e and 11a-e.Treatment of 9b-e with tri(1H-1,2,4-triazol-1-yl)phosphine oxide and subsequent reaction of 12b-e with ammonia in dioxane afforded the cytosine derivatives 13b-e which on treatment with methanolic ammonia gave the corresponding 2',3'-dideoxycytidine derivatives 14b-e and 15b-e.In contrast with the parent compounds, these alkoxymethyl derivatives had no appreciable activity against human immunodeficiency virus (HIV-1).