133648-80-3

Basic information

• Product Name: 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
• Synonyms: 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
• CAS NO: 133648-80-3
• Molecular Formula: C₁₆H₁₀Cl₃N₃O₂
• Molecular Weight: 382.6285
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 133648-80-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione(133648-80-3)
• EPA Substance Registry System: 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione(133648-80-3)

Safety Data

• Hazardous Substances Data: 133648-80-3(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Applications:
2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione is used as an anticoccidal agent for the treatment of coccidiosis in chickens. Coccidiosis is a parasitic disease that affects the intestinal tract of poultry, leading to significant economic losses in the poultry industry. 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione helps in controlling the spread of the disease by targeting the parasites responsible for coccidiosis.
Used in Pharmaceutical Applications:
As an impurity of Diclazuril (D436200), 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione plays a role in the pharmaceutical industry. Diclazuril is a potent anticoccidial drug used to treat various protozoal infections, particularly coccidiosis. The presence of 2-[3,5-Dichloro-4-[(4-chlorophenyl)Methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione as an impurity in Diclazuril may affect the drug's efficacy and safety profile, making it essential to monitor and control its levels during the manufacturing process.

Upstream product

• 7722-84-1 dihydrogen peroxide 
• 112206-56-1 2,6-dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3 H)-yl)benzeneacetamide 

Downstream Products

• 183603-78-3 2-[4-(4-chlorobenzyl)-3,5-dichlorophenyl]-hexahydro-1,2,4-triazine-3,5(3H,4H)-dione 

Relevant articles and documents

1, 2, 4-Triazin-3-one derivatives, production and use thereof

The present invention provides a novel triazine derivative of the formula STR1 wherein ring A is an optionally substituted aromatic group; X is an oxygen or sulfur atom; R1 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a hetero-atom; R2 and R3 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent =S; R4 and R5 are each independently a hydrogen atom, a halogen-atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom; R1 and R2, and R5 and R6 may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position -2 or 4 and X is an oxygen atom, R4 and R5 do not conjoin to form a chemical bond, or a salt thereof. The invention also encompasses an antiprotozoan composition comprising the novel triazine derivative or a salt thereof.

Linear discriminant and multiple regression analyses of anticoccidial triazines

Quantitative structure-activity relationships among some anticoccidial 2-(substituted-phenyl)-1,2,4-triazine-3,5-(2H,4H)-diones were studied by multiple regression analysis (MRA, the Hansch approach) and by linear discriminant analysis (LDA). With MRA the