133681-92-2

Upstream product

• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 82583-97-9 4-benzyloxy-6-iodo-3-methoxybenzaldehyde 

Downstream Products

• 1202893-47-7 ethyl 4-benzyloxy-2-iodo-5-methoxybenzoate 
• 1202892-88-3 ethyl 2-benzoyl-4,5-dihydroxy-3-nitrobenzoate 
• 1202893-55-7 ethyl 2-benzoyl-4-benzyloxy-5-methoxybenzoate 
• 1202893-94-4 2-Benzoyl-4-benzyloxy-5-methoxybenzoic acid 
• 1202893-96-6 ethyl 2-benzoyl-4-hydroxy-5-methoxybenzoate 
• 1202894-41-4 ethyl 2-benzoyl-4-hydroxy-5-methoxy-3-nitrobenzoate 

Relevant academic research and scientific papers

New cathchol deriv., pharmaceutical composition containing the same and their use (by machine translation)

PROBLEM TO BE SOLVED: To provide a new compound exhibiting a COMT inhibiting action. SOLUTION: There are disclosed a compound represented by formula (I) [in the formula, R1and R2each represents hydrogen, lower acyl, lower alkoxycar

NOVEL CATECHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, USE OF THE CATECHOL DERIVATIVE AND USE OF THE PHARMACEUTICAL COMPOSITION

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.