133684-90-9

Upstream product

• 155831-57-5 1-<<(1'-phenyl-2'-benzyloxy)ethoxy>methyl>thymine 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 65-71-4 thymin 
• 10335-95-2 2-hydroxy-2-phenylethyl benzoate 
• 156192-65-3 Benzoic acid 2-chloromethoxy-2-phenyl-ethyl ester 

Downstream Products

• 155831-69-9 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)thymine 
• 155831-65-5 1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)thymine 
• 155831-62-2 1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>thymine 

Relevant academic research and scientific papers

Synthesis and anti-HIV-1 activities of 6-arylthio and 6- arylselenoacyclonucleosides

6-Arylthio and 6-arylselenoacyclonucleosides was synthesized and tested for the ability to inhibit replication of HIV-1. Lithiation of acyclonucleosides with LDA followed by reaction with the electrophiles phenyl disulfide, diphenyl diselenide, 2,2'-dipyrdyl disulfide or 2,2'-dipyridyl diselenide afforded 6-(arylthio or arylseleno)acyclonucleosides 5a-c, 6, 7, 9, 15a-c, 17a-c. Compounds 19a-c and 20a-c were obtained by deprotection of corresponding TBDMS derivatives. Dehydrated products 16a, and 18a-c were also formed during the reactions. 5-Ethyl-6-(α-pyridylthio or α-pyridylseleno) disubstituted acyclouracils 6 and 7 were more active against HIV-1 in both MT-2 and CEM-IW cell lines than AZT, DDC, DDI or D4T. The EC50 of 6 against HIV-1 in CEM-IW cell was in the nanomolar range with a therapeutic index of 1100.