1336879-42-5

Basic information

• Product Name: C₁₇H₁₂FN₃O₂S
• Synonyms: C₁₇H₁₂FN₃O₂S
• CAS NO: 1336879-42-5
• Molecular Weight: 341.366
• Mol File: 1336879-42-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₂FN₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₂FN₃O₂S(1336879-42-5)
• EPA Substance Registry System: C₁₇H₁₂FN₃O₂S(1336879-42-5)

Safety Data

• Hazardous Substances Data: 1336879-42-5(Hazardous Substances Data)

Upstream product

• 1321618-94-3 C₁₁H₈N₂O₂S 
• 1321618-98-7 C₁₁H₇ClN₂OS 
• 399-96-2 4-amino-2-fluorophenol 
• 1194-22-5 2-methyl-4,6-dihydroxypyrimidine 

Downstream Products

• 1321619-02-6 N-(3-fluoro-4-(2-methyl-5-(thiophen-2-yl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 

Relevant articles and documents

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold

A series of thieno[2,3-d]pyrimidines and furo[2,3-d]pyrimidines were synthesized and evaluated for the c-Met inhibition. Thieno[2,3-d]pyrimidine 6b stood out as the most potent showing an IC50 of 35.7 nM. This compound displayed high inhibitory effect on cell proliferation in BaF3-TPR-Met cells and showed high selectivity for c-Met family against other 14 tested kinases. However, compound 6b was found ineffective in the c-Met-dependent U-87MG human gliobastoma xenograft model that may be relevant to its poor PK profile.