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1336879-56-1

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1336879-56-1 Usage

General Description

1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone, also known as 5-Bromoindole-3-acetyl trichloroacetone, is a chemical compound with the molecular formula C10H6BrCl3NO. It is a yellowish to beige powder that is commonly used in organic synthesis and pharmaceutical research. 1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone is a ketone derivative of indole and trichloroethane, and it is known for its potential biological activities, including anti-cancer, anti-inflammatory, and anti-fungal properties. It is also used as an intermediate in the production of various pharmaceuticals and agrochemicals. However, it is important to handle this compound with care as it may be harmful if ingested, inhaled, or comes into contact with the skin.

Check Digit Verification of cas no

The CAS Registry Mumber 1336879-56-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,6,8,7 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1336879-56:
(9*1)+(8*3)+(7*3)+(6*6)+(5*8)+(4*7)+(3*9)+(2*5)+(1*6)=201
201 % 10 = 1
So 1336879-56-1 is a valid CAS Registry Number.

1336879-56-1Relevant articles and documents

Amination/Cyclization Cascade by Acid-Catalyzed Activation of Indolenine for the One-Pot Synthesis of Phaitanthrin E

Abe, Takumi,Yamada, Koji

, p. 6504 - 6507 (2016)

We have developed a concise one-pot synthesis of phaitanthrin E derivatives, where simple starting materials undergo an acid-catalyzed intermolecular amination/intramolecular cyclization cascade.

Identification of azepinone fused tetracyclic heterocycles as new chemotypes with protein kinase inhibitory activities

Psarra, Vassiliki,Fousteris, Manolis A.,Hennig, Lothar,Bantzi, Marina,Giannis, Athanassios,Nikolaropoulos, Sotiris S.

supporting information, p. 2376 - 2385 (2016/04/26)

The design and synthesis of small tetracyclic heterocycles which bear two new regioisomeric 2-carboxyethyl-1H-pyrrole-annulated indoloazepinone scaffolds is described. An azepinone motif, which is inherent in the structures of many well studied protein kinase inhibitors, serves as prominent structural feature of the new compounds. Concise access to the new regioisomeric tetracyclic derivatives was accomplished through amide coupling of appropriate pyrrole and indole precursors followed by an intramolecular Heck coupling reaction of the intermediate amide conjugates. Preliminary evaluation of newly synthesized tetracyclic molecules against a panel of protein kinases indicated their inhibitory activities and revealed promising selectivity profiles. The new compounds displayed no significant antiproliferative activity against MCF-7 cancer cells. Interestingly, derivative 19a exhibited selective TAK1 kinase inhibitory activity and figures as a promising chemotype for the discovery of new TAK1 inhibitors.

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