13369-16-9Relevant academic research and scientific papers
A versatile method for the N,N-dialkylation of aromatic amines via Grignard reactions on N,N-bis(benzotriazolylmethyl)arylamines
Katritzky, Alan R.,Rachwal, Stanislaw,Wu, Jing
, p. 456 - 463 (2007/10/02)
Grignard reactions of N,N-bis(benzotriazolylmethyl)arylamines afford the corresponding N,N-dialkylarylamines in high yields.Electron-releasing substituents on the aryl ring facilitate the reaction.Arylamines are N,N-dialkylated with two different alkyl groups by a stepwise procedure: N-benzotriazolylmethylation of an amine followed by a Grignard reaction to introduce the first alkyl group, and repetition of the same procedure to introduce the second alkyl group.Grignard reagents derived from 1,4-dihalobutane, upon reaction with N,N-bis(benzotriazolylmethyl)arylamines, give the corresponding N-aryl-hexahydroazepines together with acyclic products.
Reactions of Allystannanes with in Situ Generated Immonium Salts in Protic Solvent: A Facile Aminomethano Destannylation Process
Grieco, Paul A.,Bahsas, Ali
, p. 1378 - 1380 (2007/10/02)
In situ generated immoniunm salts derived from primary amines and formaldehyde upon exposure to allylstannanes in protic media undergo rapid, facile aminomethano destannylation, giving rise to bishomoallylamines with no evidence of piperidine formation.
