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Usage

Uses

Used in Pharmaceutical Industry:
4-IODO-2-METHYL-5-NITROIMIDAZOLE is used as an anti-infective agent for its potent antibacterial and antifungal properties, serving to treat a range of infections caused by susceptible microorganisms. It functions by inhibiting the growth and spread of bacteria and fungi, thereby playing a crucial role in the formulation of medications aimed at combating bacterial and fungal infections.
Used in Cancer Research and Treatment:
4-IODO-2-METHYL-5-NITROIMIDAZOLE is also used as a potential anti-cancer agent, showing promise in inhibiting the growth of cancer cells. Its application in this field is of interest to researchers and medical professionals, as it may contribute to the development of new therapeutic approaches for cancer treatment.

Upstream product

• 696-23-1 2-methyl-4-nitro-1H-imidazole 
• 696-23-1 2-methyl-5-nitro-1H-imidazole 

Downstream Products

• 113121-63-4 2-methyl-4-nitro-5-phenylthioimidazole 
• 696-23-1 2-methyl-5-nitro-1H-imidazole 
• 13369-84-1 5-iodo-1,2-dimethyl-4-nitro-1H-imidazole 
• 13369-85-2 4-iodo-1,2-dimethyl-5-nitro-1H-imidazole 
• 113121-66-7 2-methyl-5-(4'-methylphenyl)thio-4-nitroimidazole 

Relevant academic research and scientific papers

Tritiated metronidazole and preparation method thereof

The invention belongs to the field of radioactive isotope labeling preparation, and particularly relates to tritiated metronidazole and a preparation method thereof. The preparation method includes: using 2-methyl-5-nitroimidazole as a raw material to react with N-iodosuccinimide to obtain 4-iodine-2-methyl-5nitroimidazole; under catalysis of palladium carbon, enabling 4-iodine-2-methyl-5nitroimidazole and tritium gas to be in tritium-halogen exchange to generate 4-3H-2-methyl-5-nitroimidazole; enabling 4-3H-2-methyl-5-nitroimidazole to react with ethylene oxide to obtain 4-3H-metronidazole. A synthetic product is purified through a prepared liquid phase to obtain4-3H-metronidazole with high specific activity (22.08Ci/g), high radiochemical purity (greater than or equal to 98%) and high chemical purity (greater than or equal to 98%). The tritiated metronidazole can be used as a radioactive tracer in studying absorption, distribution, metabolism and residue elimination of metronidazole in animal bodies.

EXPANDED THERAPEUTIC POTENTIAL IN NITROHETEROARYL ANTIMICROBIALS

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to imidazole, thiazole, and furan derivatives and their use as therapeutic agents.

Electrophilic iodination of 4-nitroimidazoles - A new high yielding method for the synthesis of 4-nitro-5-iodoimidazoles

Electrophilic iodination of 4-nitroimidazoles employing the system KI- HNO3-AcOH provided a new route for the synthesis of 4-nitro-5-iodoimidazoles in high yields. With 2-unsubstituted-4-nitroimidazoles, 2,5-diiodo-4- nitroimidazoles were obtained.