133697-12-8

Basic information

• Product Name: 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII
• Synonyms: 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII;KRM-1686;3'-Hydroxy-5'(R)-(4-sec-butylpiperazinyl)benzoxazinorifamycin;Aids008665;Aids-008665;Rifamycin viii, 1',4-didehydro-1-deoxy-1,4-dihydro-3'-hydroxy-5'-[4-(1-methylpropyl)-1-piperazinyl]-1-oxo-, [5'(R)]-
• CAS NO: 133697-12-8
• Molecular Formula: C51H64N4O13
• Molecular Weight: 941.07286
• Mol File: 133697-12-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1048.4°Cat760mmHg
• Flash Point: 587.8°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII(133697-12-8)
• EPA Substance Registry System: 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII(133697-12-8)

Safety Data

• Hazardous Substances Data: 133697-12-8(Hazardous Substances Data)

Usage

General Description

1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII is a semi-synthetic derivative of rifamycin, a group of antibiotics with strong anti-bacterial properties. It is primarily used in the treatment of tuberculosis and other mycobacterial infections. The chemical structure of 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII contains a piperazine group and a rifamycin core, which gives it its potent antibiotic activity. 1-Deoxy-1'-dehydro-3'-hydroxy-1-oxo-5'-[4-[(R)-1-methylpropyl]piperazino]rifamycin VIII works by inhibiting bacterial RNA polymerase and disrupting the synthesis of RNA, ultimately leading to the death of the bacterial cells.

InChI:InChI=1/C51H64N4O13/c1-12-26(4)54-17-19-55(20-18-54)32-22-33(57)39-35(23-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-21-16-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)24(2)14-13-15-25(3)50(63)53-41(48)45(37)61/h13-16,21-24,26-29,34,42-43,46,52,57-60H,12,17-20H2,1-11H3/b14-13+,21-16+,25-15-,53-41+/t24-,26+,27+,28+,29+,34-,42-,43+,46+,51-/m0/s1