13373-29-0

Basic information

• Product Name: ethyl 2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
• CAS NO: 13373-29-0
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.2466
• Mol File: 13373-29-0.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 409.1°C at 760 mmHg
• Flash Point: 201.2°C
• Density: 1.242g/cm³
• Vapor Pressure: 2.82E-07mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: ethyl 2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate(13373-29-0)
• EPA Substance Registry System: ethyl 2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate(13373-29-0)

Safety Data

• Hazardous Substances Data: 13373-29-0(Hazardous Substances Data)

Usage

General Description

Ethyl 2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate, also known as ethyl ferulate, is an organic compound with the chemical formula C13H13NO4. It is a derivative of ferulic acid, which is commonly found in plants and foods such as seeds, grains, and fruits. Ethyl ferulate is used in the food and cosmetic industries as an antioxidant and a flavoring agent. It also has potential pharmaceutical applications due to its anti-inflammatory and anti-cancer properties. Additionally, it has been studied for its potential as a sunscreen ingredient due to its ability to absorb ultraviolet radiation. Overall, ethyl ferulate has a wide range of potential applications in various industries due to its beneficial properties.

Upstream product

• 121-33-5 vanillin 
• 105-56-6 ethyl 2-cyanoacetate 
• 59276-35-6 4-hydroxy-3-methoxybenzaldehyde dimethylacetal 
• 85111-79-1 1-(4-vanillylidenamino-phenyl)-ethanone 
• 64-17-5 ethanol 
• 72791-61-8 2-cyano-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 

Downstream Products

• 1135-23-5 3-(4-hydroxy-3-methoxyphenyl)propionic acid 
• 1453857-36-7 6-(4-hydroxy-3-methoxyphenyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile 
• 1384968-58-4 2-cyano-3-[4-[(1,2-dihydro-2-oxoquinolin-4-yl)methoxy]-3-methoxyphenyl]-2-propenoic acid ethyl ester 
• 1384968-61-9 2-cyano-3-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)-methoxy]-3-methoxyphenyl]-2-propenoic acid ethyl ester 
• 1384968-60-8 2-cyano-3-[4-[(7-chloro-1,2-dihydro-2-oxoquinolin-4-yl)-methoxy]-3-methoxyphenyl]-2-propenoic acid ethyl ester 
• 1384968-59-5 2-cyano-3-[4-[(6-chloro-1,2-dihydro-2-oxoquinolin-4-yl)methoxy]-3-methoxyphenyl]-2-propenoic acid ethyl ester 
• 1304134-21-1 C₂₀H₁₇ClFN₃O₄S 
• 1267391-79-6 3-amino-4-[(4-hydroxy-3-methoxyphenyl)methylene]-1H-pyrazol-5(4H)-one 
• 1263308-20-8 2-amino-5-cyano-4-(4-hydroxy-3-methoxyphenyl)-6-oxo-1-{1-[4-(piperidine-1-sulfonyl)phenyl]ethylideneamino}-1,6-dihydropyridine-3-carboxylic acid ethyl ester 
• 1078-61-1 dihydrocaffeic acid 
• 540729-01-9 acetic acid 2-[3,5-dicyano-6-hydroxy-4-(4-hydroxy-3-methoxy-phenyl)-pyridin-2-ylsulfanylmethoxy]-ethyl ester 
• 540728-93-6 6-hydroxy-4-(4-hydroxy-3-methoxy-phenyl)-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile 
• 269729-18-2 2-cyano-3-(diethoxy-phosphoryl)-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid ethyl ester 
• 861515-81-3 (4-hydroxy-3-methoxy-phenyl)-succinic acid 

Relevant articles and documents

A reusable efficient green catalyst of 2d cu-mof for the click and knoevenagel reaction

[Cu(CPA)(BDC)]n (CPA = 4-(Chloro-phenyl)-pyridin-4-ylmethylene-amine; BDC = 1,4-benzenedicarboxylate) has been synthesized and structurally characterized by single crystal X-Ray diffraction measurement. The structural studies establish the copper (II) containing 2D sheet with (4,4) square grid structure. The square grid lengths are 10.775 and 10.769 ?. Thermal stability is assessed by TGA, and subsequent PXRD data establish the crystallinity. The surface morphology is evaluated by FE-SEM. The N2 adsorption?desorption analysis demonstrates the mesoporous feature (～6.95 nm) of the Cu-MOF. This porous grid serves as heterogeneous green catalyst with superficial recyclability and thermal stability and facilitates organic transformations efficiently such as, Click and Knoevenagel reactions in the aqueous methanolic medium.

Mechanically fabricated Metal–organic framework/resin composite nanoparticles for efficient basic catalysis

Zeolitic imidazolate framework-8 (ZIF-8) was successfully composited with an anionic basic resin 201?×?7 (717-resin) to provide a novel ZIF-8/717-resin composite. Its catalytic activity toward the Knoevenagel condensation reaction was evaluated. Results s

DABCO-catalyzed Knoevenagel condensation of aldehydes with ethyl cyanoacetate using hydroxy ionic liquid as a promoter

N-(2-Hydroxy-ethyl)-pyridinium chloride ([HyEtPy]Cl) was synthesized and explored as a novel promoter for 1,4-diazabicyclo [2.2.2] octane (DABCO)-catalyzed Knoevenagel condensation reactions, which showed better catalytic activity compared to other ionic liquid (IL) that had no hydroxyl group attached to the IL scaffold. The effect of hydrogen bond formation between the hydroxyl group of [HyEtPy]Cl and the carbonyl group of aldehyde played an important role in the Knoevenagel condensation reaction. In the [HyEtPy]Cl-H2O-DABCO composite system, Knoevenagel condensation reactions proceeded smoothly and cleanly, and the corresponding Knoevenagel condensation products were obtained in good to excellent yields in all cases examined. This protocol provides a versatile solvent-catalyst system, which has notable advantages such as being eco-friendly, ease of work-up and convenient reuse of the ionic liquid.