1337389-01-1Relevant articles and documents
Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells
McKay, Craig S.,Blake, Jessie A.,Cheng, Jenny,Danielson, Dana C.,Pezacki, John Paul
, p. 10040 - 10042 (2011/10/12)
Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M-1 s-1 in CD3CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells. The Royal Society of Chemistry 2011.