133740-34-8Relevant academic research and scientific papers
DAPHNANE DITERPENES OF THYMELAEA HIRSUTA
Brooks, Gavin,Evans, A. Tudor,Aitken, Alastair,Evans, Fred J.,Rizk, Abdul-Fattah M.,et al.
, p. 2235 - 2237 (1990)
Five 12-hydroxy-daphnane esters were isolated from the leaves and twigs of Egyptian Thymelaea hirsuta.These compounds were identified as gnidicin, gniditrin, genkwadaphnin, the aliphatic C-12 ester, 12-O-heptadecenoyl-5-hydroxy-6,7-epoxy-resiniferonol-9,13,14-orthobenzoate and the novel aliphatic C-12 ester 12-O-butenyl-5-hydroxy-6,7-epoxy-resiniferonol-9,13-14-orthobenzoate.
Daphnane diterpenoids for resisting prostate cancer and preparation method thereof
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Paragraph 0056-0060, (2021/03/24)
The invention discloses daphnane diterpenoids capable of resisting prostate cancer and a preparation method of the daphnane diterpenoids. It is found in the invention that the daphnane diterpenoids can significantly inhibit the proliferation of various prostate cancer cells; and the activity of some daphnane diterpenoids at a cellular level and an animal level is higher than the activity of the existing clinical targeting drug enzalutamide, and the daphnane diterpenoids have a strong synergistic effect after being combined with enzalutamide for use and are expected to become a candidate medicine for treating or assisting in treating castration-resistant prostate cancer.
