1337529-56-2

Basic information

• Product Name: L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
• Synonyms: L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester;N-[(R)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester;(S)-isopropyl 2-(((R)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate;SofosBuvir Impurity 57
• CAS NO: 1337529-56-2
• Molecular Formula: C₁₈H₁₇F₅NO₅P
• Molecular Weight: 453.297057
• Mol File: 1337529-56-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 442.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.405±0.06 g/cm3(Predicted)
• PKA: -3.81±0.70(Predicted)
• CAS DataBase Reference: L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester(1337529-56-2)
• EPA Substance Registry System: L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester(1337529-56-2)

Safety Data

• Hazardous Substances Data: 1337529-56-2(Hazardous Substances Data)

Usage

General Description

L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester is a complex organic compound that features elements of phosphorus, fluorine, oxygen, and nitrogen. It carries both the L-Alanine group and the 1-Methylethyl ester group, which are often utilized in biochemical reactions and biochemical research for their various properties. The compound also includes a pentafluorophenoxy group, an element that suggests the compound might be resistant to reactivity and degradation given fluorine's high electronegativity. This complex structure suggests it may be used in specialized scientific applications, although specific uses are not commonly found in general sources, potentially due to its complexity and the specific knowledge required to handle such a compound.

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 770-12-7 O-phenyl phosphorodichloridate 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 1256490-52-4 (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester 
• 261909-49-3 phenyl(isopropoxy-L-alaninyl) phosphorochloridate 
• 17788-07-7 2,3,4,5,6-pentafluorophenyl dichlorophosphate 
• 39825-33-7 isopropyl L-alanine 

Downstream Products

• 2095551-10-1 C₂₂H₃₀N₃O₁₀P 
• 2095551-10-1 isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF SOFOSBUVIR

The present invention relates to an improved, commercially viable and industrially advantageous process for the preparation of Sofosbuvir. The present invention involves use of reagents that are less expensive, easier to handle and eco-friendly process.

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A compound of the structure: or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an HCV virus or other disorders more fully described herein.