133761-43-0

Basic information

• Product Name: 10-Nitroisonoracronycine
• CAS NO: 133761-43-0
• Molecular Weight: 352.346
• Mol File: 133761-43-0.mol

Chemical Properties

• CAS DataBase Reference: 10-Nitroisonoracronycine(CAS DataBase Reference)
• NIST Chemistry Reference: 10-Nitroisonoracronycine(133761-43-0)
• EPA Substance Registry System: 10-Nitroisonoracronycine(133761-43-0)

Safety Data

• Hazardous Substances Data: 133761-43-0(Hazardous Substances Data)

Upstream product

• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 133761-38-3 1,3-Dihydroxy-10-methyl-5-nitro-9(10H)-acridinone 

Relevant articles and documents

Synthesis and cytostatic actions of 10- and 11-nitronoracronycins, molecular variations of cytostatically active acronycine

The syntheses of 11- and 10-nitronoracronycine (10 and 11) from 1,3-dihydroxy-10-methyl-5-nitroacridinone (7) or 1,3-dihydroxy-10-methyl-6-nitroacridinone (8), respectively, and 2-chloro-2-methyl-3-butyne are reported. In screening tests with the transplantation tumor leukemia P 388 10, 11, 7 and 1,3-dimethoxy-10-methyl-6-nitroacridinone showed cytotoxicity. 8 and 1,3-dimethoxy-10-methyl-nitroacridinone (5) proved to be inactive.