133768-71-5

Basic information

• Product Name: 3-[(3-[4-chloro-2-(dimethylcarbamoyl)phenyl]-1-{3-[(7-chloroquinolin-2-yl)methoxy]phenyl}propyl)sulfanyl]propanoic acid
• CAS NO: 133768-71-5
• Molecular Formula: C₃₁H₃₀Cl₂N₂O₄S
• Molecular Weight: 597.5519
• Mol File: 133768-71-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 782.8°C at 760 mmHg
• Flash Point: 427.2°C
• Density: 1.329g/cm³
• Vapor Pressure: 8.34E-26mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: 3-[(3-[4-chloro-2-(dimethylcarbamoyl)phenyl]-1-{3-[(7-chloroquinolin-2-yl)methoxy]phenyl}propyl)sulfanyl]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(3-[4-chloro-2-(dimethylcarbamoyl)phenyl]-1-{3-[(7-chloroquinolin-2-yl)methoxy]phenyl}propyl)sulfanyl]propanoic acid(133768-71-5)
• EPA Substance Registry System: 3-[(3-[4-chloro-2-(dimethylcarbamoyl)phenyl]-1-{3-[(7-chloroquinolin-2-yl)methoxy]phenyl}propyl)sulfanyl]propanoic acid(133768-71-5)

Safety Data

• Hazardous Substances Data: 133768-71-5(Hazardous Substances Data)

Relevant articles and documents

Practical route to a new class of LTD4 receptor antagonists

A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen-Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.