13377-50-9Relevant academic research and scientific papers
Process for the preparation of cycloaliphatic aldehydes
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, (2008/06/13)
The cycloaliphatic aldehydes of formula STR1 wherein R0, R1 and R2 represent independently a hydrogen atom or a lower alkyl from C1 to C6 and X stands for a group of formula STR2 wherein R3 and R4 represent independenly a lower alkyl radical from C1 to C3 and R5 represents a lower alkyl radical or hydrogen, provided that R1, R3 and R4 do not represent simulataneously a methyl radical whenever R0 and R2 represent each a hydrogen atom, are prepared from enol esters of formula STR3 wherein the wavy line stands for a --C--O-- bond of cis or trans configuration, Y represents an acyl group or P(O)(OR)2, wherein R stands for a lower alkyl monovalent radical or an aryl, and Z defines a group of formula STR4 wherein R3, R4 and R5 are defined as above, by cyclisation carried out by means of an acidic cyclisation agent.
