1337862-75-5

Upstream product

• 1352347-55-7 tert-butyl (2R,3S)-3-(tert-butyldimethylsilyloxy)-1-phenylhex-5-en-2-ylcarbamate 
• 1352347-54-6 (R)-tert-butyl 3-oxo-1-phenylhex-5-en-2-ylcarbamate 

Downstream Products

• 1269516-02-0 (4S,5R)-5-benzyl-4-hydroxypyrrolidin-2-one 
• 109579-12-6 (R)-5-benzyl-1-t-butoxycarbonylpyrrolidine-2,4-dione 
• 144186-19-6 (2R,3S)-tert-butyl 2-benzyl-3-hydroxy-5-oxopyrrolidine-1-carboxylate 
• 109579-13-7 (4R,5R)-5-Benzyl-1-(tert-butyloxycarbonyl)-4-hydroxypyrrolidin-2-one 

Relevant academic research and scientific papers

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine

An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four s