1337878-62-2

Basic information

• Product Name: ATI-2341
• Synonyms: ATI-2341
• CAS NO: 1337878-62-2
• Molecular Formula: C104H178N26O25S2
• Molecular Weight: 2256.82
• Mol File: 1337878-62-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Solubility: Soluble in DMSO
• CAS DataBase Reference: ATI-2341(CAS DataBase Reference)
• NIST Chemistry Reference: ATI-2341(1337878-62-2)
• EPA Substance Registry System: ATI-2341(1337878-62-2)

Safety Data

• Hazardous Substances Data: 1337878-62-2(Hazardous Substances Data)

Usage

Biological Activity

ati-2341 is a cxcr4 allosteric agonist.chemokine cxc-type receptor 4 (cxcr4) and its ligand cxcl12 mediate the retention of polymorphonuclear neutrophils and hematopoietic stem and progenitor cells in the bone marrow. drugs disrupting cxcl12-mediated chemoattraction of cxcr4-expressing cells are useful for hematopoietic stem and progenitor cells (hspcs) collection.

in vitro

ati-2341 could inhibit nkh477-induced camp accumulation in cxcr4-hek cells dose-dependently, but showed no effect in naive hek-293 parental cells. pretreatment of cxcr4- hek cells with pertussis toxin completely abrogated the ability of ati-2341 to inhibit camp accumulation. ati-2341 could also induce a dose-dependent increase in intracellular calcium in cells transfected with wild-type cxcr4 whereas having no effect on untransfected cells. activation of such signaling pathway by ati-2341 was dependent on a fully functional cxcr4 receptor since ati-2341 was not able to mobilize calcium in cells transfected with a cxcr4 receptor variant [1].

in vivo

ati-2341 could induce dose-dependent peritoneal recruitment of polymorphonuclear neutrophils (pmns) when i.p. administered to mice. however, when systemically administered by i.v. bolus, ati-2341 acted as an antagonist and could dose-dependently mediate release of pmns from the bone marrow of mice and cynomolgus monkeys. in addition, ati-2341-mediated release of granulocyte/macrophage progenitor cells from the bone marrow was further confirmed by colony-forming assays [1].

IC 50

194 nm

references

[1] tchernychev b et al. discovery of a cxcr4 agonist pepducin that mobilizes bone marrow hematopoietic cells. proc natl acad sci u s a.2010 dec 21;107(51):22255-9.