1337970-95-2Relevant academic research and scientific papers
Regio- and diastereoselective fluorination of alicyclic β-amino acids
Kiss, Lorand,Forro, Enik,Fustero, Santos,Fueloep, Ferenc
, p. 6528 - 6534 (2011/11/05)
A regio- and stereoselective approach to fluorinated β- aminocyclohexene or cyclohexane esters has been developed, starting from a bicyclic β-lactam (1). The procedure involves six or seven steps, based on regio- and stereoselective iodolactonization, lactone opening and hydroxy-fluorine exchange. The method has been extended to the synthesis of fluorinated amino ester enantiomers.
