1337988-12-1

Basic information

• Product Name: C₃₆H₄₃N₇O₁₂
• Synonyms: C₃₆H₄₃N₇O₁₂
• CAS NO: 1337988-12-1
• Molecular Weight: 765.777
• Mol File: 1337988-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₄₃N₇O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₄₃N₇O₁₂(1337988-12-1)
• EPA Substance Registry System: C₃₆H₄₃N₇O₁₂(1337988-12-1)

Safety Data

• Hazardous Substances Data: 1337988-12-1(Hazardous Substances Data)

Upstream product

• 21743-75-9 (1H-tetrazol-5-yl)-acetic acid 
• 1337987-98-0 C₂HF₃O₂*C₃₃H₄₁N₃O₁₁ 
• 1337987-97-9 C₃₃H₄₁N₃O₁₁ 
• 303-81-1 novobiocin 

Relevant articles and documents

Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities

Synthetic derivatives of the natural product antibiotic novobiocin were synthesized in order to improve their physiochemical properties. A Mannich reaction was used to introduce new side chains at a solvent-exposed position of the molecule, and a diverse panel of functional groups was evaluated at this position. Novobiocin and the new derivatives were tested for their binding to gyrase B and their antibacterial activities against Staphylococcus aureus, Mycobacterium tuberculosis, Francisella tularensis and Escherichia coli. While the new derivatives still bound the gyrase B protein potently (0.07-1.8 μM, IC50), they had significantly less antibacterial activity. Two compounds were identified with increased antibacterial activity against M. tuberculosis, with a minimum inhibitory concentration of 2.5 μg/ml.