1338055-80-3

Upstream product

• 65287-34-5 2-chloropyridine-4-carbonyl chloride 
• 6313-54-8 2-chloroisonicotinic acid, 
• 1338055-75-6 2-(2-chloro-4-pyridyl)-4H-chromone-4-one 
• 1338055-77-8 2-(2-chloropyridin-4-yl)-3-iodochromone 
• 1765-93-1 4-fluoroboronic acid 
• 1338055-78-9 3-bromo-2-(2-chloropyridin-4-yl)chromone 
• 1338055-73-4 2-acetylphenyl 2-chloroisonicotinate 
• 1338055-74-5 1-(2-chloro-4-pyridin-yl)-3-(2-hydroxyphenyl)propane-1,3-dione 

Downstream Products

• 1338055-86-9 3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone 
• 1338055-85-8 2-(2-(cyclohexylamino)pyridin-4-yl)-3-(4-fluorophenyl)chromone 
• 1338055-81-4 3-(4-fluorophenyl)-2-(2-(isopropylamino)pyridin-4-yl)chromone 
• 1338055-82-5 2-(2-(butylamino)pyridin-4-yl)-3-(4-fluorophenyl)chromone 
• 1338055-84-7 2-(2-((3-(dimethylamino)propyl)amino)pyridin-4-yl)-3-(4-fluorophenyl)chromone 
• 1338055-87-0 2-(2-(benzylamino)pyridin-4-yl)-3-(4-fluorophenyl)chromone 
• 1338055-83-6 3-(4-fluorophenyl)-2-(2-((3-methoxypropyl)amino)pyridin-4-yl)chromone 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of chromone-based p38 MAP kinase inhibitors

3-(4-Fluorophenyl)-2-(4-pyridyl)chromone derivatives were synthesized and evaluated as p38 MAP kinase inhibitors. Introduction of an amino group in the 2-position of the pyridyl moiety gave p38α inhibitors with IC50 in the low nanomolar range (