1338057-68-3

Basic information

• Product Name: (E)-1-methyl-4-styrylpiperidine
• Synonyms: (E)-1-methyl-4-styrylpiperidine
• CAS NO: 1338057-68-3
• Molecular Weight: 201.312
• Mol File: 1338057-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-methyl-4-styrylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-methyl-4-styrylpiperidine(1338057-68-3)
• EPA Substance Registry System: (E)-1-methyl-4-styrylpiperidine(1338057-68-3)

Safety Data

• Hazardous Substances Data: 1338057-68-3(Hazardous Substances Data)

Upstream product

• 4110-77-4 (E)-β-chlorostyrene 
• 63463-36-5 (1-methyl-4-piperidyl)magnesium chloride 
• 5570-77-4 4-chloro-1-methylpiperidine 
• 3883-13-4 2,2,2-trichloroethylbenzene 

Relevant articles and documents

Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow

Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon–carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp?Csp3 and Csp2?Csp3 bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity.