133816-01-0Relevant academic research and scientific papers
Preparation of Substituted Tetrahydroisoquinolines by Pd(II)-Catalyzed NH2-Directed Insertion of Michael Acceptors into C-H Bonds Followed by NH2-Conjugated Addition
Mancinelli, Andrea,Alamillo, Carla,Albert, Joan,Ariza, Xavier,Etxabe, Haizea,Farràs, Jaume,Garcia, Jordi,Granell, Jaume,Quijada, F. Javier
, p. 911 - 919 (2017)
3,3-Disubstituted tetrahydroisoquinolines are prepared in one step from Michael acceptors and 2-phenylethylamines under Pd catalysis and Ag2CO3 as an oxidant. Presumably, activation of an ortho C-H bond of the aromatic ring with Pd(II) is directed by the primary amine to form a palladacycle. Insertion of the olefin, subsequent conjugated addition of the amine, and reductive elimination of Pd(0) affords the expected products. Silver carbonate is not necessary when 2-phenylethylamines are converted previously to N-benzoyloxy-2-phenylethylamines.
Synthesis and application of enantioenriched functionalized α-tetrasubstituted α-amino acids from biocatalytic desymmetrization of prochiral α-aminomalonamides
Zhang, Li-Bing,Wang, De-Xian,Zhao, Liang,Wang, Mei-Xiang
experimental part, p. 5584 - 5591 (2012/08/13)
Catalyzed by Rhodococcus erythropolis AJ270, an amidase-containing microbial whole cell catalyst in neutral phosphate buffer at 30 °C, a number of prochiral α-substituted α-aminomalonamides underwent highly efficient and enantioselective hydrolytic desymm
