1338232-94-2Relevant academic research and scientific papers
Synthesis and evaluation of compounds that induce readthrough of premature termination codons
Jung, Michael E.,Ku, Jin-Mo,Du, Liutao,Hu, Hailiang,Gatti, Richard A.
, p. 5842 - 5848 (2011)
A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.
PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS
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Paragraph 0248; 0261, (2013/10/22)
Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
