1338236-55-7Relevant academic research and scientific papers
CuBr2 catalyzed bromination/oxidation of isochromans to benzaldehyde derivatives
Zhou, Mei-Yan,Kong, Shan-Shan,Zhang, Ling-Qiong,Zhao, Ming,Duan, Jin-Ao,Ou-Yang, Zhen,Wang, Min
supporting information, p. 3962 - 3964 (2013/07/25)
A series of isochromans were oxidized and brominated by using 1.2 equiv of CuBr2 in CH3CN at reflux to give the corresponding bromo benzaldehydes in moderate yields. A plausible mechanism for this transformation has been suggested.
Copper-catalyzed enantioselective additions to oxocarbenium ions: Alkynylation of isochroman acetals
Maity, Prantik,Srinivas, Harathi D.,Watson, Mary P.
supporting information; experimental part, p. 17142 - 17145 (2011/12/13)
We have developed an enantioselective, copper(I)-catalyzed addition of terminal alkynes to racemic isochroman acetals. This method is one of the first transition-metal-catalyzed approaches to enantioselective additions to prochiral oxocarbenium ions. In this reaction, TMSOTf is used to form the oxocarbenium ion in situ under conditions compatible with simultaneous formation of the chiral copper acetylide. By using a bis(oxazoline) ligand, good yields and enantioselectivities are observed for a variety of enantioenriched 1-alkynyl isochromans.
