133825-80-6Relevant articles and documents
Synthesis and Evaluation of 11C- And 18F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents
Arteaga, Janna,Brooks, Allen F.,Hill, James R.,Scott, Peter J. H.,Shao, Xia,Sherman, Phillip S.,Stauff, Jenelle,Viglianti, Benjamin L.,Wong, Ka Kit,Wright, Jay S.
, p. 1299 - 1304 (2020)
PD-132301, an inhibitor of sterol O-acyltransferase 1 (SOAT1; also known as acyl-coenzyme A:cholesterol acyltransferase-1, ACAT1), is under clinical investigation for numerous adrenal disorders. Radiolabeled SOAT1 inhibitors could support drug discovery a
SOLID DRUG FORM OF N-(2,6-BIS(1-METHYLETHYL)PHENYL)-N'-((1-(4-(DIMETHYLAMINO)PHENYL)CYCLOPENTYL)METHYL)UREA HYDROCHLORIDE AND COMPOSITIONS, METHODS AND KITS RELATED THERETO
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, (2016/04/26)
A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to “ATR-101”) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.
Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
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, (2008/06/13)
Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and for lowering blood