133825-81-7

Basic information

• Product Name: 1-({1-[4-(dimethylamino)phenyl]cyclopentyl}methyl)-3-[2,6-di(propan-2-yl)phenyl]urea hydrochloride (1:1)
• CAS NO: 133825-81-7
• Molecular Formula: C₂₇H₄₀ClN₃O
• Molecular Weight: 458.079
• Mol File: 133825-81-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 528.1°C at 760 mmHg
• Flash Point: 273.2°C
• Vapor Pressure: 3.05E-11mmHg at 25°C
• CAS DataBase Reference: 1-({1-[4-(dimethylamino)phenyl]cyclopentyl}methyl)-3-[2,6-di(propan-2-yl)phenyl]urea hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-({1-[4-(dimethylamino)phenyl]cyclopentyl}methyl)-3-[2,6-di(propan-2-yl)phenyl]urea hydrochloride (1:1)(133825-81-7)
• EPA Substance Registry System: 1-({1-[4-(dimethylamino)phenyl]cyclopentyl}methyl)-3-[2,6-di(propan-2-yl)phenyl]urea hydrochloride (1:1)(133825-81-7)

Safety Data

• Hazardous Substances Data: 133825-81-7(Hazardous Substances Data)

Usage

General Description

The chemical "1-({1-[4-(dimethylamino)phenyl]cyclopentyl}methyl)-3-[2,6-di(propan-2-yl)phenyl]urea hydrochloride (1:1)" is a synthetic compound consisting of a urea derivative with a hydrochloride salt. It is composed of a cyclopentylmethyl-phenylurea core with dimethylamino and di(propan-2-yl)phenyl functional groups attached. This chemical is commonly used in research and pharmaceutical applications due to its potential as a therapeutic agent, with reported activities in fields such as anti-cancer, anti-diabetic, and anti-hyperlipidemia. Additionally, its hydrochloride form enhances its solubility in aqueous environments, making it more readily available for experimental use.

Upstream product

• 50522-40-2 2,6-diisopropylaniline hydrochloric acid salt 
• 133825-80-6 N-<2,6-bis(1-methylethyl)phenyl>-N'-<<1-<4-(dimethylamino)phenyl>cyclopentyl>methyl>urea 
• 133825-88-4 1-<4-(dimethylamino)phenyl>cyclopenatnecarbonitrile 
• 133825-87-3 4-[1-(aminomethyl)cyclopentyl]-N,N-dimethylaniline 

Relevant articles and documents

Synthesis and Evaluation of 11C- And 18F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

PD-132301, an inhibitor of sterol O-acyltransferase 1 (SOAT1; also known as acyl-coenzyme A:cholesterol acyltransferase-1, ACAT1), is under clinical investigation for numerous adrenal disorders. Radiolabeled SOAT1 inhibitors could support drug discovery a

SOLID DRUG FORM OF N-(2,6-BIS(1-METHYLETHYL)PHENYL)-N'-((1-(4-(DIMETHYLAMINO)PHENYL)CYCLOPENTYL)METHYL)UREA HYDROCHLORIDE AND COMPOSITIONS, METHODS AND KITS RELATED THERETO

A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to “ATR-101”) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.