1338322-19-2Relevant academic research and scientific papers
A dual-catalysis approach to the asymmetric steglich rearrangement and catalytic enantioselective addition of O-acylated azlactones to isoquinolines
De, Chandra Kanta,Mittal, Nisha,Seidel, Daniel
supporting information; experimental part, p. 16802 - 16805 (2011/12/03)
A dual-catalysis approach, namely the combination of an achiral nucleophilic catalyst and a chiral anion-binding catalyst, was applied to the Steglich rearrangement to provide α,α-disubstituted amino acid derivatives in a highly enantioselective fashion. Replacement of the nucleophilic co-catalyst for isoquinoline resulted in a divergent reaction pathway and an unprecedented transformation of O-acylated azlactones. This strategy provided highly substituted α,β-diamino acid derivatives with excellent levels of stereocontrol.
