1338349-24-8

Basic information

• Product Name: N-(1-benzylpiperidin-4-yl)-2-[1-(4-fluorophenyl)cyclohexyl]acetamide
• CAS NO: 1338349-24-8
• Molecular Weight: 408.559
• Mol File: 1338349-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-benzylpiperidin-4-yl)-2-[1-(4-fluorophenyl)cyclohexyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-benzylpiperidin-4-yl)-2-[1-(4-fluorophenyl)cyclohexyl]acetamide(1338349-24-8)
• EPA Substance Registry System: N-(1-benzylpiperidin-4-yl)-2-[1-(4-fluorophenyl)cyclohexyl]acetamide(1338349-24-8)

Safety Data

• Hazardous Substances Data: 1338349-24-8(Hazardous Substances Data)

Upstream product

• 1496-36-2 1-(4-fluorophenyl)cyclohexan-1-ol 
• 1338349-22-6 [1-(4-fluorophenyl)cyclohexyl]acetaldehyde 
• 1338349-20-4 1-(1-allylcyclohexyl)-4-fluorobenzene 
• 1225477-99-5 [1-(4-fluorophenyl)cyclohexyl]acetic acid 
• 1338349-21-5 3-[1-(4-fluorophenyl)cyclohexyl]propane-1,2-diol 

Relevant articles and documents

Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4- fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents

We synthesized and evaluated inhibitory activity against T-type Ca 2+ channels for a series of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl) butyl]piperidine-4-carboxamide derivatives. Structure-activity relationship studies have revealed that dialkyl substituents at the benzylic position play an important role in increasing inhibitory activity. Oral administration of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(2-phenylethyl)piperidine-4-carboxamide (20d) lowered blood pressure in spontaneously hypertensive rats without inducing reflex tachycardia, which is often caused by traditional L-type Ca2+ channel blockers.