133840-96-7

Basic information

• Product Name: 2-Chloro-6-(trifluoromethoxy)-benzothiazole
• Synonyms: 2-Chloro-6-(trifluoromethoxy)-benzothiazole;2-chloro-6-trifluoromethoxylbenzothiazole;2-Chloro-6-(trifluoromethoxy)-1,3-benzothiazole;2-Chloro-6-(trifluoroMethoxy)-Benzo[d]thiazole
• CAS NO: 133840-96-7
• Molecular Formula: C₈H₃ClF₃NOS
• Molecular Weight: 253.6287296
• Mol File: 133840-96-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 250.786 °C at 760 mmHg
• Flash Point: 105.472 °C
• Appearance: /
• Density: 1.599 g/cm³
• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.20±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-6-(trifluoromethoxy)-benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-(trifluoromethoxy)-benzothiazole(133840-96-7)
• EPA Substance Registry System: 2-Chloro-6-(trifluoromethoxy)-benzothiazole(133840-96-7)

Safety Data

• Hazardous Substances Data: 133840-96-7(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H3ClF3NOS/c9-7-13-5-2-1-4(3-6(5)15-7)14-8(10,11)12/h1-3H

Upstream product

• 1744-22-5 Riluzole 
• 133840-98-9 2-hydrazinyl-6-(trifluoromethoxy)benzo[d]thiazole 
• 461-82-5 4-(trifluoromethoxy)aniline 

Downstream Products

• 133840-97-8 2-methylamino-6-trifluoromethoxy-benzothiazole 
• 235101-85-6 SKA-5 

Relevant articles and documents

Synthesis, crystal structure, and antinociceptive effects of some new riluzole derivatives

Nine N-alkylated derivatives of riluzole were synthesized in order to obtain new compounds with potential antinociceptive activity. Riluzole was firstly transformed into (6-trifluoromethoxy-benzothiazol-2-yl)-hydrazine, then it was chlorinated by SOCl2 to obtain 2-chloro-6-trifluoromethoxy-benzothiazole. This intermediate product was treated with nine alkylamines to give N-alkylated derivatives of riluzole respectively. The structures of compounds were confirmed by means of elemental analysis, IR, 1H NMR, and 13C NMR. The synthetic route was optimized and four novel crystals were obtained by recrystallization. This study investigated the antinociceptive activity of some N-alkylated derivatives of riluzole by hot plate test in mice. The relationship between antinociceptive activity and the doses of 4b, 4c, 4h, 4g, and riluzole had been studied. Compared with the control group (0 mg/kg), the effects of compounds 4b and 4h showed a significant increase (13.78 ± 2.89 s, 12.89 ± 2.94 s, respectively). Compound 4c showed extreme significant increase (18.07 ± 3.08 s) in the time mice spent on the hot plate. The compounds 4b, 4c, and 4h had increased the latency time compared to the blank solvent group. They have potential application in developing new drug candidates with antinociceptive activity.

NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.

Preparation and use of aryl alkyl acid derivatives for the treatment of obesity

This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.