133844-95-8

Basic information

• Product Name: methyl 2,3-dihydrobenzofuran-7-carboxylate
• Synonyms: methyl 2,3-dihydrobenzofuran-7-carboxylate;Methyl 2,3-dihydro-1-benzofuran-7-carboxylate;7-Benzofurancarboxylic acid, 2,3-dihydro-, Methyl ester;7-BENZOFURANCARBONYL CHLORIDE, 2,3-DIHYDRO-, METHYL ESTER
• CAS NO: 133844-95-8
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178
• Mol File: 133844-95-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 2,3-dihydrobenzofuran-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,3-dihydrobenzofuran-7-carboxylate(133844-95-8)
• EPA Substance Registry System: methyl 2,3-dihydrobenzofuran-7-carboxylate(133844-95-8)

Safety Data

• Hazardous Substances Data: 133844-95-8(Hazardous Substances Data)

Usage

General Description

Methyl 2,3-dihydrobenzofuran-7-carboxylate is a chemical compound with the molecular formula C11H12O3. It is a derivative of benzofuran, a heterocyclic compound with a benzene ring fused to a furan ring. Methyl 2,3-dihydrobenzofuran-7-carboxylate is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals. It has been studied for its potential biological activities, such as antioxidant and anti-inflammatory properties. The compound is also used as a flavoring agent in the food industry, adding a sweet, floral aroma to food products.

Upstream product

• 31456-98-1 methyl 3-allyl-salicylate 
• 91715-56-9 3-Formylmethyl-salicylsaeure-methylester 
• 6282-42-4 methyl 2-allyloxybenzoate 
• 496-16-2 2.3-dihydrobenzofuran 
• 67-56-1 methanol 
• 35700-40-4 2,3-dihydrobenzofuran-7-carboxylic acid 
• 99517-45-0 methyl benzofuran-7-carboxylate 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 
• 13661-90-0 2-vinyloxy-benzoic acid methyl ester 
• 75855-24-2 2-Hydroxy-3-vinyl-benzoic acid methyl ester 
• 123266-63-7 2,3-Dihydro-7-benzofurancarboxylic acid chloride 

Downstream Products

• 1616110-67-8 methyl 5-amino-2,3-dihydrobenzofuran-7-carboxylate 
• 856679-33-9 methyl 5-[(2-methoxy-5-methylphenyl)sulfonyl]-2,3-dihydro-1-benzofuran-7-carboxylate 
• 90484-22-3 7-benzofuranylcarboxylic acid 
• 123266-63-7 2,3-Dihydro-7-benzofurancarboxylic acid chloride 
• 99517-45-0 methyl benzofuran-7-carboxylate 
• 35700-40-4 2,3-dihydrobenzofuran-7-carboxylic acid 

Relevant articles and documents

Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors

Novel substituted 2,3-dihydrobenzofuran-7-carboxamide (DHBF-7-carboxamide) and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide (DHBF-3-one-7-carboxamide) derivatives were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). A structure-based design strategy resulted in lead compound 3 (DHBF-7-carboxamide; IC50 = 9.45 μM). To facilitate synthetically feasible derivatives, an alternative core was designed, DHBF-3-one-7-carboxamide (36, IC50 = 16.2 μM). The electrophilic 2-position of this scaffold was accessible for extended modifications. Substituted benzylidene derivatives at the 2-position were found to be the most potent, with 3′,4′-dihydroxybenzylidene 58 (IC50 = 0.531 μM) showing a 30-fold improvement in potency. Various heterocycles attached at the 4′-hydroxyl/4′-amino of the benzylidene moiety resulted in significant improvement in inhibition of PARP-1 activity (e.g., compounds 66-68, 70, 72, and 73; IC50 values from 0.718 to 0.079 μM). Compound 66 showed selective cytotoxicity in BRCA2-deficient DT40 cells. Crystal structures of three inhibitors (compounds (-)-13c, 59, and 65) bound to a multidomain PARP-1 structure were obtained, providing insights into further development of these inhibitors.

BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS

Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.

2,3-Dichlor-5,6-dicyano-1,4-benzochinon (DDQ) als Dehydrierungsmittel zur Synthese von Benzofurancarbonsaeuren

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