1338443-27-8 Usage
General Description
N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide tosylate is a chemical compound with potential biological and pharmaceutical applications. It contains a picolinamide core structure, modified with a methyl group and substituted with a trifluoromethylbenzamido group and phenoxy group. The tosylate salt form of the compound provides stability and solubility in aqueous environments, making it suitable for use in pharmaceutical formulations and research. N-Methyl-4-(4-(3-(trifluoroMethyl)benzaMido)phenoxy)picolinaMide Tosylate could potentially be used as a drug candidate or as a chemical probe for studying biological pathways. Its unique molecular structure and properties make it a promising candidate for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1338443-27-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,8,4,4 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1338443-27:
(9*1)+(8*3)+(7*3)+(6*8)+(5*4)+(4*4)+(3*3)+(2*2)+(1*7)=158
158 % 10 = 8
So 1338443-27-8 is a valid CAS Registry Number.
1338443-27-8Relevant articles and documents
Synthesis and biological evaluation of novel 4-(4-formamidophenylamino)-N-methylpicolinamide derivatives as potential antitumor agents
Hu, Min,Meng, Nana,Xia, Yong,Xu, Youzhi,Yu, Luoting,Zeng, Xiuxiu,Zhou, Shuyan
, (2021/06/11)
A novel series of 4-(4-formamidophenylamino)-N-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT116) at low micromolar concentrations and the most potent analog 5q possessed broad-spectrum antiproliferative activity. Experiments in vivo demonstrated that 5q could effectively prolong the longevity of colon carcinoma-burdened mice and slow down the progression of cancer cells by suppression of angiogenesis and the induction of apoptosis and necrosis.
