1338560-69-2Relevant academic research and scientific papers
Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines
Kojima, Naoto,Suga, Yuki,Hayashi, Hiromi,Yamori, Takao,Yoshimitsu, Takehiko,Tanaka, Tetsuaki
scheme or table, p. 5745 - 5749 (2011/10/19)
The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
