1338561-06-0

Basic information

• Product Name: C₂₀H₁₈F₃NO₃
• Synonyms: C₂₀H₁₈F₃NO₃
• CAS NO: 1338561-06-0
• Molecular Weight: 377.363
• Mol File: 1338561-06-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₈F₃NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₈F₃NO₃(1338561-06-0)
• EPA Substance Registry System: C₂₀H₁₈F₃NO₃(1338561-06-0)

Safety Data

• Hazardous Substances Data: 1338561-06-0(Hazardous Substances Data)

Upstream product

• 501433-14-3 methyl 2,6-difluoro-3-iodobenzoate 
• 1338561-05-9 C₁₇H₁₃F₃O₃ 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1338561-04-8 C₁₄H₉F₃O₂ 
• 1338561-03-7 C₁₅H₁₁F₃O₂ 
• 446-48-0 o-fluorobenzyl bromide 

Downstream Products

• 1338560-95-4 6-(2-fluorobenzyl)-1-benzyl-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1338560-98-7 6-(2-fluorobenzyl)-1-(2-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1338561-25-3 C₂₅H₁₉F₂NO₃ 
• 1338561-29-7 C₂₅H₁₈F₃NO₃ 
• 1338561-40-2 C₂₄H₁₇F₂NO₃ 
• 1338561-44-6 C₂₄H₁₆F₃NO₃ 
• 1338561-15-1 C₂₅H₁₉F₄NO₃ 
• 1338561-12-8 C₂₅H₂₀F₃NO₃ 

Relevant articles and documents

Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors

A series of new 5-hydroxylquinolone-3-carboxylic acids (HQCAs) with various aryl or benzyl substituents on N-1 position were synthesized and evaluated for their anti-HIV activity in C8166 cell culture. Most of the target compounds displayed activity against wide-type HIV-1 in the low micromolar range in infected C8166 cells. The most active compound 5g exhibited activity against wild-type HIV-1 and HIV-1 mutant virus A17 with an EC50 value of 3.17 and 17.88 μM, respectively. The biological results and the docking study revealed that the substitution pattern on N-1 position of the quinolone core might contribute to physicochemical properties of HQCAs and resulted in great influence on their antiviral potency.