1338562-86-9

Upstream product

• 1338563-36-2 5-(4-methoxybenzoyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid 
• 1338563-24-8 ethyl 5-(2-nitrophenylsulfonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate 
• 1338563-23-7 N-(2-chloroethyl)-2-nitro-N-(prop-2-ynyl)benzenesulfonamide 
• 1338563-37-3 5-(4-methoxybenzoyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide 
• 1338563-35-1 ethyl 5-(4-methoxybenzoyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate 
• 1029720-98-6 ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate 
• 100-09-4 4-methoxybenzoic acid 

Relevant academic research and scientific papers

Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform

Acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide are potent sub-type selective HDAC6 inhibitors. Constrained heterocyclic analogs based on 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine show further enhanced HDAC6 selectivity and inhibitory activity in ce

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein X1, X2, R1a, R1b, R1c, R1d, n, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention al