133858-28-3Relevant academic research and scientific papers
Preparation method of 2-amino-1, 3, 4-oxadiazole compound and prepared compound
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Paragraph 0028-0037, (2021/08/28)
The invention belongs to the field of medical chemistry, and particularly relates to a preparation method of a 2-amino-1, 3, 4-oxadiazole compound and the compound prepared by the preparation method. According to the method, the 1, 3, 4-oxadiazole compoun
A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives
Gan, Zongjie,Han, Lei,Hu, Xiangnan,Long, Binyu,Tang, Qiang,Tian, Binghua,Wang, Chenyu,Wang, Zifan,Wu, Yue,Yu, Yu
supporting information, (2021/08/18)
A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room tempera
Synthesis of 2-Amino-1,3,4-oxadiazoles through Elemental Sulfur Promoted Cyclization of Hydrazides with Isocyanides
Bao, Wenhu,Chen, Chuang,Yi, Niannian,Jiang, Jun,Zeng, Zebing,Deng, Wei,Peng, Zhihong,Xiang, Jiannan
, p. 1611 - 1618 (2017/10/06)
A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been developed. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino- 1,3,4-oxadiazoles are efficiently obtained in good yields.
Hypervalent iodine(V) mediated mild and convenient synthesis of substituted 2-amino-1,3,4-oxadiazoles
Prabhu, Girish,Sureshbabu
experimental part, p. 4232 - 4234 (2012/09/07)
A simple protocol for the synthesis of 2-amino-1,3,4-oxadiazoles starting from the corresponding acylhydrazides by cyclodesulfurization of intermediate acylthiosemicarbazides mediated by o-iodoxybenzoic acid in good yields has been described. The protocol
A SYNTHESIS OF 1,3,4-OXADIAZOLES VIA THE AZA-WITTIG REACTION OF N-ACYLAMINO IMINOTRIPHENYLPHOSPHORANES
Froeyen, Paul
, p. 11 - 15 (2007/10/02)
The aza-Wittig reaction of N-acylamino iminotriphenylphosphoranes with carbon disulfide, isocyanates and isothiocyanates, lead to the very reactive heterocumulenic systems (5) and (2) which undergo spontaneous cyclization to 5-substituted 2-mercapto-1,3,4-oxadiazoles (6) and 2-amino-1,3,4-oxadiazoles (3), respectively.
