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1338596-74-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1338596-74-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,8,5,9 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1338596-74:
199 % 10 = 9
So 1338596-74-9 is a valid CAS Registry Number.

1338596-74-9Downstream Products

1338596-74-9Relevant articles and documents

Insight into the functional and structural properties of 3-arylcoumarin as an interesting scaffold in monoamine oxidase B inhibition

Matos, Maria Joao,Vilar, Santiago,Garcia-Morales, Veronica,Tatonetti, Nicholas P.,Uriarte, Eugenio,Santana, Lourdes,Vina, Dolores

, p. 1488 - 1500 (2014)

The design, synthesis, pharmacological evaluation, and theoretical studies of a new series of halogenated 3-arylcoumarins were carried out with the aim of finding new structural and biological features. This series displays several alkyl, hydroxy, halogen, and/or alkoxy groups in both benzene rings of the 3-arylcoumarin scaffold. Most of the compounds studied show high affinity and selectivity for the human monoamine oxidase B (hMAO-B) isoenzyme, with IC 50 values in the low nanomolar and picomolar range. Most of the evaluated compounds display higher MAO-B inhibitory activity and selectivity than selegiline (the reference compound). Coumarin 12 (3-(3-bromophenyl)-6- methylcoumarin) is the most active compound (IC50=134 pM), being 140-fold more active than selegiline and showing the highest specificity for hMAO-B. To better understand the structure-activity relationships, docking experiments were carried out on human monoamine oxidase (A and B) structures. Finally, the prediction of passive blood-brain partitioning, based on in silico derived physicochemical descriptors, was performed. Coumarins crossing the barrier: The design and synthesis of a new series of halogenated 3-arylcoumarins are described. Monoamine oxidase A and B in vitro inhibition studies, in silico prediction of passive blood-brain partitioning, and docking calculations showed most of the 3-arylcoumarin compounds to be potent and selective.

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