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Usage

General Description

2,4-Pentanedione, 3-fluoro-3-methyl- (9CI) is a chemical compound with the molecular formula C6H10O2. It is a fluoro-substituted derivative of 2,4-pentanedione, which is commonly used as a flavoring agent in the food industry. The addition of a fluoro and methyl group to the compound may alter its properties and reactivity. It may exhibit similar chemical reactivity and uses as its parent compound, but with differences in its flavor profile or biological activity. The compound may have potential applications in the food, pharmaceutical, or chemical industries, but further research is needed to fully understand its properties and potential uses.

Upstream product

• 815-57-6 3-Methyl-2,4-pentanedione 

Relevant academic research and scientific papers

Reactions of trifluoroamine oxide: A new method for selective fluorination of 1,3-diketones and β-ketoesters

Fluorination of 1,3-diketones and β-ketoesters with trifluoroamine oxide in the presence of tetrabutylammonium hydroxide (TBAH) provides a one step route to mono- and difluoro-products selectively fluorinated at the α-position in good yields.

Preparation of fluorinated dicarbonyls

PCT No. PCT/GB94/02547 Sec. 371 Date Feb. 21, 1997 Sec. 102(e) Date Feb. 21, 1997 PCT Filed Nov. 18, 1994 PCT Pub. No. WO95/14646 PCT Pub. Date Jun. 1, 1995A method for the fluorination of 1,3-diketones and 1,3-ketoesters is disclosed.

Direct fluorination of 1,3-dicarbonyl compounds

In acid media, 1,3-diketones and 1,3-keloesters can be fluorinated in high yield and often with high conversion mainly to the corresponding 2-fluoro- compounds. Diesters such as diethyl malonate do not react with fluorine under the same reaction conditions. The mechanism of these reactions has been investigated and while the identity of the electrophilic fluorinating species is uncertain, we believe that the essential features of the reaction pathway are understood. Copyright

Direct Fluorination of 1,3-Dicarbonyl Compounds

1,3-Dicarbonyls, such as 1,3-diketones and 1,3-ketoesters, react directly with elemental fluorine at room temperature to give the corresponding 2-fluoro- and, in some cases, 2,2-difluoro-compounds in high yield.

N-Fluorobisimides. Efficient reagents for the fluorination of 1,3-dicarbonyl derivatives

Fluorination of 1,3-dicarbonyl derivatives with N-fluorobisimides, (CF3SO2)2NF (1), results in the formation of 2-fluoro- or 2,2-difluoro-1,3-dicarbonyl analogs, depending on the reaction conditions.High yields are obtained for a variety of structural types.In the case of 1,3-dicarbonyl derivatives with low enol content, only the sodium enolates react with 1.Thus 1 has been demonsrtated to be perhaps the best fluorinating reagent for the fluorination of 1,3-dicarbonyl derivatives.All of the 2-fluoro-1,3-dicarbonyl products exist predominantly as keto tautomers.

N-Fluoro Perfluoroalkylsulphonimides: Efficient Reagents for the Fluorination of 1,3-Dicarbonyl Derivatives

Fluorination of 1,3-dicarbonyl derivatives with N-fluoro sulphonimides afforded either 2-fluoro or 2,2-difluoro products in high yields.