1338604-33-3Relevant academic research and scientific papers
PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS
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Page/Page column 41, (2013/02/28)
The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity
Fulp, Alan,Bortoff, Katherine,Zhang, Yanan,Seltzman, Herbert,Snyder, Rodney,Maitra, Rangan
, p. 5711 - 5714 (2011/10/09)
CB1 receptor antagonists that are peripherally restricted were targeted. Compounds with permanent charge as well as compounds that have increased polar surface area were made and tested against CB1 for binding and activity. Sulfonamide and sulfamide with high polar surface area and good activity at CB1 were rationally designed and pharmacologically tested. Further optimization of these compounds and testing could lead to the development of a new class of therapeutics to treat disorders where the CB1 receptor system has been implicated.
