1338721-76-8

Basic information

• Product Name: dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate
• Synonyms: dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate
• CAS NO: 1338721-76-8
• Molecular Weight: 580.634
• Mol File: 1338721-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate(1338721-76-8)
• EPA Substance Registry System: dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate(1338721-76-8)

Safety Data

• Hazardous Substances Data: 1338721-76-8(Hazardous Substances Data)

Upstream product

• 6914-71-2 dimethyl 1,1-cyclopropanedicarboxylate 
• 1322091-24-6 4-fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Relevant articles and documents

Synthesis of 2,3,4,11b-tetrahydro-1 H-pyridazino[6,1-a]isoquinolines via the three-component reaction of 2-alkynylbenzaldehydes, a sulfonohydrazide and dimethyl cyclopropane-1,1-dicarboxylate

A three-component reaction of 2-alkynylbenzaldehydes, a sulfonohydrazide and dimethyl cyclopropane-1,1-dicarboxylate, co-catalyzed by silver(I) triflate and nickel(II) perchlorate hexahydrate, is described, which affords 2,3,4,11b-tetrahydro-1H-pyridazino[6,1-a]isoquinolines in moderate to good yields. A possible reaction pathway that proceeds via a tandem 6-endo-cyclization and [3+3] cycloaddition sequence is proposed. Georg Thieme Verlag Stuttgart ? New York.