1338797-41-3Relevant academic research and scientific papers
Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases
Salomon, Emmanuel,Schmitt, Marjorie,Marapaka, Anil Kumar,Stamogiannos, Athanasios,Revelant, Germain,Schmitt, Céline,Alavi, Sarah,Florent, Isabelle,Addlagatta, Anthony,Stratikos, Efstratios,Tarnus, Céline,Albrecht, Sébastien
, (2018/10/21)
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assays wer
Regioselective synthesis of the 1-bromo-4-phenyl-tetrahydro-7-amino- benzocyclohepten-6-one, a subnanomolar aminopeptidase-N/CD13 inhibitor
Al-Lakkis-Wehbe, Mira,Roux, Lionel,Charrier, Cédric,Alavi, Sarah,Le Nou?n, Didier,Defoin, Albert,Tarnus, Céline,Albrecht, Sébastien
, p. 6447 - 6455 (2012/08/28)
A regioselective synthesis of the title 1-bromo-4-phenyl-tetrahydro-7- amino-benzocyclohepten-6-one 2 has been pursued and develop in order to allow a large scale synthesis of this highly potent and selective APN inhibitor (K i 60 pM). The pivo
A novel amino-benzosuberone derivative is a picomolar inhibitor of mammalian aminopeptidase N/CD13
Maiereanu, Carmen,Schmitt, Céline,Schifano-Faux, Nadge,Le Nou?n, Didier,Defoin, Albert,Tarnus, Céline
, p. 5716 - 5733 (2011/10/12)
A new class of low molecular weight, highly potent and selective non peptidic inhibitors of aminopeptidase N (APN/CD13) is described. We report the synthesis and in vitro evaluation of racemic substituted analogues of 7-amino-benzocyclohepten-6-one 1a. We
