13388-86-8

Upstream product

• 576-26-1 2.6-dimethylphenol 
• 18350-98-6 2,6-dimethylphenyl dichlorophosphoric acid 
• 141793-36-4 dichloro(2,6-dimethylphenoxy)phosphine 

Downstream Products

• 1094213-58-7 [Cu(2,6-dimethylphenyl phosphato)(3,5-di-tert-butyl pyrazole)]4 
• 576-26-1 2.6-dimethylphenol 

Relevant academic research and scientific papers

Synthesis, mechanistic interpretation and kinetic study of 2,6 Di-methylphenyl phosphate monoester in acid medium

Extensive kinetic study has been carried out on the hydrolysis of mono-2,6-dimethylphenyl phosphate ester in acid 0.1 to 6.0 mol. dm3 HCl and buffers from 1.24 to 7.46 pH at 97± 0.5°C in water. Systematic ionic data proves the presence of acid catalyzed hydrolysis. The monoester has been found to be hydrolysis by conjugate acid, mono-negative, neutral and di -negative species. The inorganic phosphate obtained in overall hydrolysis has been estimated by Allen's modified method. Study of the reaction and dioxane- water mixture suggested the nature of transition state in which charges are developed due to bimolecular attack of water molecule. Comparative isokinetic rate data of similarly substituted other phosphate monoesters, whose mechanism is known, supported P-O bond fission.

Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.